Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy.
نویسندگان
چکیده
منابع مشابه
Basophil Functions During Type 2 Inflammation: Initiators, Regulators and Effectors
Recent studies have identified several previously unrecognized functions of basophils in multiple models of Th2 cytokine-dependent immunity and inflammation. In addition to their established role as effector cells in inflamed tissues, findings now indicate that basophils express MHC class II and co-stimulatory molecules, can migrate into draining lymph nodes, present antigen to naive CD4 + T ce...
متن کاملBasophil effector function and homeostasis during helminth infection.
Basophils are effector cells of the innate immune system that are associated with allergic inflammation and infections with helminth parasites. However, their development and in vivo functions are largely unknown. Here, we characterize basophil development, turnover, tissue localization, and effector function during infection with the helminth Nippostrongylus brasiliensis. Our results demonstra...
متن کاملSuppression of type 2 immunity and allergic airway inflammation by secreted products of the helminth Heligmosomoides polygyrus.
Allergic asthma is less prevalent in countries with parasitic helminth infections, and mice infected with parasites such as Heligmosomoides polygyrus are protected from allergic airway inflammation. To establish whether suppression of allergy could be mediated by soluble products of this helminth, we tested H. polygyrus excretory-secretory (HES) material for its ability to impair allergic infla...
متن کاملHelminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness.
It has been shown that the presence of certain helminth infections in humans, including schistosomes, may reduce the propensity to develop allergies in infected populations. Using a mouse model of schistosome worm vs worm + egg infection, our objective was to dissect the mechanisms underlying the inverse relationship between helminth infections and allergies. We have demonstrated that conventio...
متن کاملLow-Dose Intestinal Trichuris muris Infection Alters the Lung Immune Microenvironment and Can Suppress Allergic Airway Inflammation
Immunological cross talk between mucosal tissues such as the intestine and the lung is poorly defined during homeostasis and disease. Here, we show that a low-dose infection with the intestinally restricted helminth parasite Trichuris muris results in the production of Th1 cell-dependent gamma interferon (IFN-γ) and myeloid cell-derived interleukin-10 (IL-10) in the lung without causing overt a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of immunology
دوره 177 3 شماره
صفحات -
تاریخ انتشار 2006